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Efficient Antibacterial Ketoconazole Powder CAS 65277-42-1 Ketoconazole
| Ketoconazole Basic information | |
| Product Name: | Ketoconazole |
| Synonyms: | ,3-dioxolan-4-yl)methoxy)phenyl)-,cis-;fungarest;fungoral;ketoconazol;ketoderm; ketoisdin;kw-1414;nizoral |
| CAS: | 65277-42-1 |
| MF: | C26H28Cl2N4O4 |
| MW: | 531.43 |
| EINECS: | 265-667-4 |
| Product Categories: | Active Pharmaceutical Ingredients;Organics;Antifungals for Research and Experimental Use;Antitumors for Research and Experimental Use;Biochemistry; Antibiotic Explorer;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals; API;API's;Antifungal;Heterocycles;Isotopically Labeled Pharmaceutical Reference Standard;KETOZOLE |
| Mol File: | 65277-42-1.mol |
| Ketoconazole Chemical Properties | |
| Melting point | 146°C |
| density | 1.4046 (rough estimate) |
| refractive index | -10.5 ° (C=0.4, CHCl3) |
| Fp | 9ºC |
| storage temp. | 2-8°C |
| solubility | methanol: soluble50mg/mL |
| pka | pKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain) |
| form | Off-white solid |
| color | white to light yellow |
| optical activity | [α]20/D -1 to 1°, c = 4 in methanol |
| Water Solubility | Soluble in DMSO, ethanol, chloroform, water, and methanol. |
| Merck | 145302 |
| CAS DataBase Reference | 65277-42-1(CAS DataBase Reference) |
| Application | An antifungal drug for the treatment of athlete's foot and excessive dandruff |
Spec. Ketoconazole
| Items | Specification | Results |
| Appearance | White or almost white crystalline powder | confirms |
| Identification | IR | Confirms |
| Melting range, °C | 148.0~152.0 | 148.0~150. |
| Specific Rotation | -1.0o~+1.0o | 0o |
| Loss on Drying, % | ≤ 0.50 | 0.1 |
| Residue on Ignition, % | ≤ 0.10 | 0.06 |
| Heavy Metals, % | ≤ 0.002 | < 0.002 |
| Chromatographic purity, % | ≤ 2.0 | Confirms |
| Residue Solvent, % | ||
| Acetoacetate | ≤ 0.50 | 0.3 |
| Dimethyl sulfoxide | ≤ 0.50 | 0.2 |
| Bacteria | Not more than 10 per g | Confirms |
| Mold & yeast | None-detected | Confirms |
| Assay, % | 98.0~102.0 | 99.2 |
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Ketoconazole is a synthetic antifungal drug used to prevent and treat fungal skin infections, especially in immunocompromised patients such as those with AIDS or those on chemotherapy. Ketoconazole is sold commercially as an anti-dandruff shampoo, topical cream, and oral tablet.
Xi'an Tian Guangyuan Biotech Co., Ltd.
Sophie Lee/Sales Manager
Tel: 86-29-86333380
Web:tgybio.en.made-in-china.com
XIAN Tian Guangyuan Biotech Co.,Ltd.Was founded in May 2003, is a professional animal and plant Extracts
modernand advanced enterprise object, chemical intermediates and active ingredients of Natural active
throughout the country,plant extracts industry, research and development, production,Marketing and other
areas have a strong strength.The company is headquartered in the outskirts of Xi'an, under research and
development center as well as analysisand testing center, comprehensive strength in the national forefront
of the industry.Companies rely on the wisdom andinnovation of advanced technology, scientific management
and all the staff and a good team spirit, will enable the companyto develop a domestic industry with sik-class
product quality and international competitiveness of enterprises.
